![]() ![]() Maya and basketball player Ben Simmons dated for around a year and a half before splitting in August 2022. Maya and basketball player Ben Simmons dated for around a year and a half. > Every time Stormzy has mentioned Maya Jama since their split > Maya Jama responds after being spotted with 'mystery man' > Who is Stormzy dating in 2023? Girlfriend, ex-girlfriends & more However, Maya's representatives went on to squash the rumours, confirming that the reports were indeed false but that the pair remain "great friends." They were spotted at the same event amid reports claiming they were "very much" back in each other's lives. Three years later, in 2022, Maya and Stormzy were linked again following her split from then-fiancé basketball star Ben Simmons. Following the split, Stormzy went on to shut down speculation that he had cheated on the Glow Up host. She began dating the chart-topping musician back in 2016 when she was 20 years old, and the pair were hailed as 'couple goals' by many.ĭespite this, the pair broke up in 2019, much to their fan's surprise. The MIJ Masks founder's most famous relationship was the four years she spent with British rapper Stormzy.
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![]() Without wasting more time, let’s take a look at some common doggie growls and what they mean: Play Growlingĭogs growl when they want you to play with them. What Do Different Dog Growls Mean?ĭogs growl for various reasons, and it is understandable if all pooch growls sound similar to an untrained ear. As a dog owner, however, it’s important to differentiate between the various dog growls, as this will help you take the necessary and appropriate actions. However, before we go into all this, let’s examine the different types of dog growls and what they mean. Today’s article focuses on the reasons for growling in dogs, how to react when your dear Fido suddenly starts growling at you or your family, and how to distinguish between a playful and aggressive growl. Dogs typically communicate by growling when attempts to make their feelings known with body language are not successful.Ī growl is usually the first obvious sign of aggression in a doggie, but it can mean a whole lot of other things. What is a dog growl? A growl is a low, guttural sound produced by dogs as a means of communicating with people or other animals. Give your dog their own spaces, time, and plenty of breed-appropriate mental and physical stimulation, and you're on your way to a healthy relationship between your dog and child.Dogs growl to make their feelings known, but how can you understand what your pooch is trying to say? Read on to find out about the different types of dog growls and what they mean. Your baby and dog can have positive interactions, but it may not necessarily be how you envisioned. We cover these techniques in the Dogs to Diapers course and will help you devise a game plan to give your dog the jobs and roles they need to succeed at home.ĭogs to Diapers will help you learn to recognize your dog's stressors and triggers and work to maintain the boundaries they need. Your dog needs help understanding new coping behaviors and household management. ![]() Separating your child and dog until a training plan is implemented is the first step toward success. Make no mistake this is a serious situation that requires immediate intervention. It is a dog who genuinely wishes to control the child within the environment and is confident in its ability to win an ensuing battle if necessary. This is not a dog that feels defensive or helpless or has had thresholds pushed. The issue arises when we have a dog growling in a controlling manner. We don't want our dogs to feel they can correct our children however, this means we have to step up and take that responsibility ourselves. Like people, dogs have thresholds, and an accumulation of stressors can cause them to resort to defensive behavior to enforce their boundaries. Don't let your child harass or annoy your dog, even if it seems tolerant at first. ![]() Personal space and resources are common boundaries that dogs can feel threatened over. Importantly, a warning growl when a dog feels threatened can easily escalate into a nip if ignored, which is why we don't want to correct it and eliminate our warning sign. Generally, the two states of mind associated with threatening growls are defensiveness and aggression. This is where we get into more serious growls. Keep interactions calm and positive, and choose interactive activities such as playing fetch instead of physical play. If your dog is play-growling while playing with your child, the best course of action is to monitor and rein in the play before it gets too rowdy. The type of play dogs engage in with each other can contain behaviors such as nipping, mouthing, and physical contact that isn't safe or appropriate for human play, particularly children. ![]() However, even though this means your dog is not being aggressive toward your baby, we still don't want your dog to see them as a littermate or playmate. This type of growl takes place in a playful state of mind, usually during the roughhousing and mock-fighting that makes up dogs' typical play behavior. If you've ever watched your dog play with other dogs, you've probably already heard a play growl. Let's talk about a few different types of growls and how to differentiate them. The fact that your dog is trying to communicate its needs before taking action should be reassuring. Different types can tell you what your dog is feeling and how to help. Growling is a form of communication for dogs. You may already be having these thoughts and feel guilty about it.įirst thing's first, your dog needs your help. It can trigger feelings of anxiety, stress, and thoughts of having to rehome the dog. One of the scariest moments a new parent can experience is their beloved family dog growling at their baby. ![]() ![]() ![]() nagoomation Office Lady Zelda (The Legend of Zelda) ElijahZX. We have anime, hentai, porn, cartoons, my little pony, overwatch, pokemon, naruto, animatedRule 34, if it exists there is porn of it. Princess Zelda unhappy with facial animated. It's most likely the second option considering they wouldn't be able to have a romantc relationship while she was a princess and. This version of Zelda (Legend of Zelda: BOTW) could either be 17 or 117 since she was 17 when Ganon first attacked and 117 after Link's 100 year recovery. shell gas station near me with car wash Tue, - 21:37. 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Synchronize files/folders between a local directory and remote server.Specify the local and remote directory path, then drag-and-drop your file to the Transmit icon in the Dock. With DropSend, you can send a file/folder to the right destination.Then drag-and-drop file/folder to the icon, it’ll get uploaded to the server. Save any server as a droplet in the Finder.Or, you may also drag an item from the Finder into Transmit. If you drop items over a sub-folder, they will get uploaded into that folder. To upload a file/folder, drag-and-drop from the local file browser to any remote server. To the left, click the disk icon to switch between a file browser and a connection panel. ![]() The focused file browser displays the directory in blue text. At the top, the browser path bar is highlighted in black and blue. The dual-pane interface has some interesting design elements.
![]() ![]() UTEP LIBRARY BLUMBERG AUDITORIUM: 1st FLOOR, 1900 Wiggins Rd., El Paso, TX 79968ĭreaming in Chinese: From Canton to El PasoĬantonese immigrants were among the more than 110,000 Chinese who traveled to the United States during the Gold Rush era. Join us for the presentations and reception. Lucero is a BA candidate in Art History and Communication Studies. Bush’s portraits of wounded Iraq/Afghanistan soldiers with the psychology of Lea’s Life magazine images from World War II. Guadalupe Lucero’s presentation compares the works of former President George W. Pichardo Urrutia is an MFA candidate, a published writer, and producer for KTEP’s Words on a Wire radio program. Iliana Pichardo Urrutia presents “Tom Lea: Explorations in Landscape.” It includes prose, poetry, and three phonographic works of sound art. UTEP students are selected to receive the fellowship on a project that deepens knowledge of Tom Lea’s art and writings. MEETING SPOT: 1500 McKelligon Canyon Dr., El Paso, TX 79904 ![]() Wear sturdy shoes and bring water for the hike. After hiking down the canyon, join us in the picnic area to eat authentic Chrysanthemum Cake and assemble an adorable Chinese lantern to remember our ancestors. Meet at the west end of the canyon picnic area near the Ron Coleman trailhead for this family-friendly event. Jim Tolbert, director of Celebration of Our Mountains, recounts the tradition of Double Ninth Festival, and Holly Cobb of the Tom Lea Institute relates the romantic story of when Tom Lea proposed to Sarah Dighton in the Canyon. We will recreate the tradition with a moderate level hike at the east end of McKelligon Canyon. Tom Lea wrote, “Mount Franklin is a gaunt hardrock mountain, standing against the sky like a piece of the world’s uncovered carcass.” The Chinese commemorate their ancestors by climbing a mountain and eating chrysanthemum cake during the Double Ninth Festival or Chongyang Festival. MEXICAN CONSULATE,910 E San Antonio Ave., El Paso, TX 79901 The United States is reciprocating by placing Benito Juárez - Child to Man at the Chamizal National Memorial on Sept. After the Chamizal Treaty was signed in 1963, Mexico honored Abraham Lincoln near the Parque Chamizal in Juárez. Although they never met, they corresponded and supported one another when both were faced by civil war. ![]() It began with the changing course of the Rio Grande during the presidencies of Abraham Lincoln and Benito Juárez, a pure-bred Zapotec Indian. Mexican Consul Mauricio Ibarra Ponce de León hosts historian and opera singer José Mario Sanchez Soledad for an evening highlighting the significance of the Chamizal Treaty in settling a 100-year boundary dispute between Mexico and the United States. ![]() ![]() ![]() Very swollen chalazia or styes may be treated with the following methods by your doctor.įollow these tips to help prevent chalazia and styes. You may also prefer to wash the area gently with a little bit of watered-down baby shampoo. After using a warm compress, it may be helpful to gently massage around the area to promote draining.Ĭreams and ointments are available to treat chalazia and styes.Use compresses a few times per day to open the clogged gland and allow the infected area to drain and heal.It may be helpful to microwave the cloth for 10 seconds or so to keep it warm. Soak a wash cloth with very warm water and put it over the infected area for about 10 minutes.Treat chalazia and styes with warm compresses. Only touch the area with clean hands and wash your hands afterwards. Do not wear eye makeup or contact lenses until your infection heals. Try your best to prevent spreading the infection. It is important that you do not try to squeeze or pop chalazia and styes yourself. Mild cases may go away on their own within a few days, without treatment from your doctor. Many treatment options are available depending on the severity of your chalazion or stye. If you get chalazia or styes often, you should also visit your doctor. If you have any of the following symptoms, see your doctor: Visit your doctor if your chalazion or stye does not begin to heal within a few days, or gets worse. A large chalazion may cause blurry vision. Often, a chalazion forms from an internal stye. Overtime the lump may become red and tender to the touch. If your stye is external you may notice more signs of infection.Ī chalazion is a swollen lump on your eyelid. Stye symptomsĪn internal stye may be difficult to recognize as it may have very mild symptoms, especially if it remains small. They occur at the base of the eyelashes and may look like a pimple. External styeĮxternal styes are typically caused by an infected eyelash follicle. :( I do vastly prefer the microwaved damp washcloth over the Bruder/usb style eye masks. At most it might (might) help it resolve earlier, but more likely than not it will still be there months later and hardened into a nice cyst that has to be cut out. They occur under the eyelid and most frequently near the lash line. Ive never had hot compresses do anything to either a stye or chalazion. Internal styes are typically caused by an infected oil producing gland. It is typically small, pink or red, and causes a great deal of discomfort. StyesĪ stye, also known as a hordeolum, is a painful lump that grows on your lash line or just under your eyelid. ![]() The main differences are where the bump is and the amount of pain it causes. ![]() Sometimes it can be hard to distinguish the difference between chalazia and styes. They can range from mild to severe and cause discomfort or pain. Chalazia and styes are bumps that occur on the eye lid from clogged and infected oil glands or lash follicles. ![]() ![]() ![]() IF YOU DO NOT WISH TO ACCEPT THE PRODUCT UNDER THESE TERMS, YOU MAY CHOOSE NOT TO ACCEPT BY SELECTING "I decline." AND NOT INSTALLING THE SOFTWARE. 13.4.1 Old and new disk partition layoutsīY ACCEPTING, YOU (ORIGINAL PURCHASER) INDICATE YOUR ACCEPTANCE OF THESE TERMS.13.3.10 Old and new disk partition layouts.13.3.8 Selecting partition transfer method.13.3.5 Old and new disk partition layout.11.2 Automatic image creation using cron service.11.1.3 Specific options (options specific for individual trueimagecmd commands).11.1.2 Common options (options common for most trueimagecmd commands).11.1 Backup, restore and other operations in the console mode (trueimagecmd).8.1.1 Activating and deactivating Acronis Startup Recovery Manager.6.3.11 Restoration summary and executing restoration.6.3.9 Restoring several partitions at once.6.3.8 Changing the restored partition size and location.6.3.7 Changing the restored partition file system.6.3.6 Changing the restored partition type.6.3.5 Selecting a target disk/partition.6.3.4 Selecting a disk/partition to restore.6.3 Restoring disks/partitions or files from images. ![]() 6.2 Restoring files and folders from file archives.Restoring the backup data under X Window System 5.3.7 Fast incremental/differential backup.5.3.4 Before/after data capture commands.5.2 Backing up disks and partitions (image backup).5.1 Backing up files and folders (file backup).Creating backup archives under X Window System Main program interface under X Window System 3.7 Backing up software and hardware RAID arrays.3.2 Full, incremental and differential backups.3.1 The difference between file archives and disk/partition images.General information and proprietary Acronis technologies 2.3 Running Acronis True Image Server for Linux.2.2 Installing Acronis True Image Server for Linux.1.2 Features of Acronis True Image Server for Linux.True Image Home - 2011 - Netbook Edition.True Image Home - 2010 - Netbook Edition.True Image - enterprise virtual edition. ![]() ![]() We will renew your card after you have cleared all fines, fees, and overdue materials from your record. Renew your card by presenting the card and identification with your current name and residential address at any library branch. You are responsible for all items borrowed on your card. The Fulton County Library System will follow applicable Federal and State laws relating to the confidentiality of library records. Parent/Guardians may use their ID to obtain cards for their children.To obtain a library card, you must show a form (or forms) of identification that shows who you are and where you live. Here are some kinds of identification that you can use to obtain or activate your library card. Identification requirements for a library card The $40 fee gives you full borrowing privileges with the Fulton County Library System. Non-residents may apply for a library card at any of our library branches by completing an application, showing identification with a current name and address, and paying a non-refundable fee of $40 per person per year. We do need the signature of the business or property owner before we can open the account. In many cases, we can issue a card right away. Visit any of our branches, complete a short application, and show us a current business license or current paid property tax bill. When you own a business or property in Fulton County or the City of Atlanta in DeKalb you’re eligible for a free library card with the Fulton County Library System. Library cards for business and property owners We support education! If you teach at any licensed educational organization in Fulton County or in the City of Atlanta, including the City of Atlanta in DeKalb, or if you are a homeschooling parent in the same area, we offer you an educator’s card. We’ll be happy to check your address.Ĭhildren enjoy libraries, and parents are invited to apply for even the youngest members of their family. A parent or legal guardian must sign applications for children who are under 13 years old. Please note: Sometimes people who have an Atlanta mailing address may not live in Fulton County or in the City of Atlanta in DeKalb. We also issue free cards to people who are currently teaching in Fulton County and the City of Atlanta in DeKalb, (including homeschooling parents), to people who are going to a school in Fulton County and the City of Atlanta in DeKalb, and to people who own property or a business in the area. We issue free cards to everyone who lives in Fulton County, as well as people who live inside the legal city limits of the City of Atlanta, including the part of the City of Atlanta that is in DeKalb County. To convert this online card to a physical card simply visit one of Fulton County Library System's 34 locations, show us some identification with your current name and address, and we’ll issue you a physical card that you can use right away. Residents who do not currently have a library card can apply for one online and have a temporary library card issued, the " Online Library Card Application." The card will allow access to one of our most popular digital resources, OverDrive, as well as the Libby app for downloading of ebooks and audiobooks. How do I get a library card if the library is closed? You can opt out at any time, should you not wish to receive news and updates from the Library System. Please note, that upon completing your library card application, you will be added to our patron e-news list. Once you have picked up your card you may begin enjoying all the resources the library has to offer. ![]() After you submit the application online, you will receive an email with instructions on how to permanently activate your card at any branch. Visit one of Fulton County Library System's 34 branches, complete an application, show us some identification with your current name and address, and we’ll issue you a card that you can use right away. ![]() Cardholders may also reserve meeting rooms at no charge. Cardholders may borrow up to 50 items at one time. The library system offers books, eBooks, e-Audiobooks, DVDs, CDs, books on CD, books on MP3, and videos for you to borrow to use and enjoy, with additional services available online through the library system’s website. Your Fulton County Library System card can open the door to a world of information. ![]() ![]() ![]() Then, 20 µl cell suspension was mixed with 160 µl 0.7% LMA (low melting point agarose) and spread onto frosted slides that were coated with 1% NMA (normal melting point agarose). A total of 72 h after treatment, the cells were harvested and resuspended with PBS. ![]() The cells were cultured as aforementioned. Single-cell gel electrophoresis assay (SCGE)ĭNA damage was assessed using the SCGE assay as described by Singh et al ( 15) and Gao et al ( 16) with slight modifications (electrophoresis condition: 25 V, 300 mA, 25 min). The IC 50 values were obtained using GraphPad Prism (version 6.00 GraphPad Software, Inc., La Jolla, CA, USA). The values were expressed as the percentage of control, medium. All experiments were repeated at least three times. Then, the plates were measured at 450 nm (Multiskan FC Thermo Fisher Scientific, Inc.). Briefly, CCK-8 solution was added (10 µl/well), and the culture plates were stirred gently followed by incubation in CO 2 incubator at 37☌ for 2 h. After 72 h treatment, cell viability was assessed by Cell Counting Kit-8 (CCK-8) assay (Beyotime Institute of Biotechnology, Haimen, China). Ltd, Pudong, China), alone and in combination. Then, the medium was replaced with 100 µl fresh medium containing various concentrations of itraconazole (Xi'an Janssen Pharmaceutical, Shanxi, China) and 5-FU (Shanghai Xudong Haipu Pharmaceutical Co. SGC-7901 cells were seeded into Nunclon-96-well flat bottom plates at a density of 5,000 cells per well containing 100 µl growth medium per well and incubated for 24 h. Whether itraconazole is able to affect the survival of gastric cancer patients was also assessed. In vitro experiments were performed to determine the effects of itraconazole and 5-FU alone or in combination in SGC-7901 cells. The purpose of the present article is to assess the effects of itraconazole on gastric cancer. 5-FUis a type of pyrimidine antagonist with cytotoxic mechanisms it has the ability to incorporate its metabolites as false precursors into DNA to cause DNA instability ( 9, 10). A number of these reports have concluded that itraconazole has potent and selective inhibitory activity on the proliferation of endothelial cells and multiple key aspects of tumor angiogenesis in vitro and in vivo ( 7, 8).ĥ-fluorouracil (5-FU) is widely used as a potent drug for the treatment of gastric cancer. However, an increasing number of reports have revealed that itraconazole has a potential antitumor function ( 2– 6). Itraconazole kills fungi by inhibiting lanosterol 14a-demethylase, which is essential for the conversions of lanosterol to ergosterol in fungi and lanosterol to cholesterol in humans ( 2). Itraconazole is a Food and Drug Administration-approved antifungal drug belonging to the azole family. ![]() Nevertheless, gastric cancer mortality still accounts for a significant proportion of all cancer mortalities ( 1). The incidence rate of gastric cancer has declined worldwide (10–20% per decade), from being the most common cancer in 1980 to the fourth most common cancer in 2017 ( 1). Itraconazole alone and in combination with 5-FU was able to inhibit the growth of gastric cancer in vitro, and it was able to prolong the survival of patients with gastric cancer. in vivo, itraconazole was able to improve the outcome of 5-FU-based chemotherapy. Combination itraconazole and 5-FU treatment showed a synergetic anticancer effect in SGC-7901 cells. These effects were promoted in cells treated with both itraconazole and 5-FU. Itraconazole treatment inhibited the proliferation and altered cell cycle in SGC-7901 cells while promoting early apoptosis and DNA damage. Medical records of patients with gastric cancer were retrospectively reviewed, and the patients treated with itraconazole were selected for the present study. Single-cell gel electrophoresis was used to estimate DNA damage. Cell cycle distribution was determined by PI staining and flow cytometer. Cell proliferation was assessed by a Cell Counting Kit-8 assay, and apoptosis was assessed by Annexin V/propidium iodide (PI) staining and flow cytometry. In the present study, SGC-7901 gastric cancer cells were chosen to assess the anticancer effects of itraconazole in combination with 5-FU. Whether combining itraconazole with other anticancer compounds such as 5-fluorouracil (5-FU), a potent drug used in the treatment of gastric cancer, is unknown and warrants further study. Recent studies reported that itraconazole has potential anticancer activity. ![]() ![]() ![]() If you have texture you want to address, you may want to consider a serum with lactic or glycolic acid to help gently exfoliate your skin. If you have sun damage, a serum packed with vitamin C or azelaic acid would be a good choice. The best serum is one that targets your specific skin type or concern, or both.įor example, if you have dry skin, a serum with ingredients that will boost moisture and address fine lines, like one with hyaluronic acid, would be a great choice. Adjust your routine based on the kind of skin you have, and how it reacts to what you’re using. Once you have nailed this routine down, consider adding other products such as eye cream, a serum, an exfoliant mask, and other spot treatments. Repeat this every morning, with the addition of sunscreen. To start a skin care routine, get a hold of the basics: cleanser, toner, moisturizer, and sunscreen.Įvery night, begin by cleansing your skin before bed, followed by toner and moisturizer. If you have dry skin, it’s important to know that cleansers that lather use surfactants that can ultimately dry your skin, so it’s probably best for you to stick with a cleanser that’s milky or lotion-like.įrequently asked questions How do I start a skin care routine? Some reviewers say the creamy texture took some getting used to, while others say they would’ve preferred a cleanser that lathers. However, the lotion-like texture may be different for those who are used to a foaming cleanser. This cleanser aims to do a good job at providing a deep clean without stripping the skin of its natural moisture. It also includes hyaluronic acid to help retain moisture. ![]() ![]() Like the rest of CeraVe’s skin care products - which are developed with dermatologists - this cleanser is formulated with three essential ceramides to help restore the skin’s protective barrier. With nearly 50,000 5-star reviews on Amazon, CeraVe’s Hydrating Facial Cleanser is highly praised by people with dry and sensitive skin. Cons: lotion-like texture can take some getting used to. ![]() |
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